April 22 is the 112th day of the year (113th in leap years). There are 253 days remaining.
- 1842 — John Lynch died.
- 1849 — Thomas W. Piper is born.
- 1884 — Hugo Schenk died.
- 1918 — Helmuth Schmidt is apprehended.
- 1953 — Elmer Helm died.
- 1954 — Nikolay Sakharov is born.
- 1960 — Vladimir Mukhankin is born.
- 1977 — Chantal Gras is murdered by Émile Louis.
- 1978 — Cynthia Irene Waxman is murdered by Charles Jackson.
- 1978 — Barbara Ann Cox is murdered by Nathaniel Burkett.
- 1984 — April Brunais is murdered by Michael Ross.
- 1984 — Leslie Shelley is murdered by Michael Ross.
- 1985 — Gary Ridgway's victim, Angela Marie Girdner, is found (suspected victim).
- 1987 — Morris Solomon Jr. is apprehended.
- 1991 — Tadeusz Kwaśniak is apprehended.
- 1991 — Claire Peck is murdered by Beverley Allitt.
- 1999 — Luis Garavito is apprehended.
- 1999 — Peter Dupas is apprehended.
- 2003 — Juan Rodriguez Chavez died.
- 2004 — Kim Young-hee is murdered by Jeong Nam-gyu.
- 2005 — Wendy Dehoop is allegedly murdered by Israel Keyes (suspected victim).
- 2008 — Daniel Lee Siebert died.
- 2020 — Margaret Wairimu and Jeremiah Maina are murdered by Dishon Muturi Nderi.